✦ LIBER ✦

Mobility of concanavalina receptors on the surface membrane of lymphocytes from normal persons and patients with chronic lymphocytic leukemia

✍ Scribed by Hannah Ben-Bassat; Natan Goldblum; Noga Manny; Leo Sachs

Publisher: John Wiley and Sons
Year: 1974
Tongue: French
Weight: 316 KB
Volume: 14
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910140310

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Lymphocytes, isolated from the peripheral blood of normal persons and patients with chronic lymphocytic leukemia, have been studied for cap formation and agglutinability by Concanavalin A (Con A). Twenty‐eight to 32% of the lymphocytes from 12 normal persons formed a cap and there was a similar frequency in separated B cells. The lymphocytes from 12 patients with chronic lymphocytic leukemia showed 6‐10% cells with a cap. Lymphocytes from the leukemic patients had a higher degree of Con‐A‐induced agglutinability than the lymphocytes from normal persons, and both types of cell bound a similar number of Con A molecules. The results indicate that there are differences in the mobility of Con A receptors on the surface membrane of lymphocytes from normal persons and patients with chronic lymphocytic leukemia.

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