Mn(II), Co(II), Zn(II), Fe(III) and U (VI) complexes of 2-acetylpyridine 4N-(2-pyridyl) thiosemicarbazone (HAPT); structural, spectroscopic and biological studies

✍ Scribed by Usama El-Ayaan; Magdy M. Youssef; Shar Al-Shihry

• Publisher: Elsevier Science
• Year: 2009
• Tongue: English
• Weight: 541 KB
• Volume: 936
• Category: Article
• ISSN: 0022-2860
• DOI: 10.1016/j.molstruc.2009.07.042

✦ Synopsis

The present work carried out a study on transition metal ion complexes which have been synthesized from 2-acetylpyridine 4 N-(2-pyridyl) thiosemicarbazone (HAPT) 1. These complexes namely [Zn(HAPT)Cl 2 ] 2, [Mn (HAPT)Cl 2 ] 3, [Co (HAPT)Cl 2 ] 4, [Fe(APT)Cl 2 (H 2 O)] 5 and [UO 2 (HAPT)(OAc) 2 ] 6, were characterized by elemental analysis, spectral (IR, 1 H NMR and UV-vis) and magnetic moment measurements. Thermal properties and decomposition kinetics of all compounds are investigated. The interpretation, mathematical analysis and evaluation of kinetic parameters (E, A, DH, DS and DG) of all thermal decomposition stages have been evaluated using Coats-Redfern equation. The biochemical studies showed that, complexes 3 and 6 have powerful and complete degradation effect on the both DNA and protein. The SOD-like activity exhibited that complex 3 has a strong antioxidative properties. The antibacterial screening demonstrated that, the free ligand (HAPT), complexes 2, 3 and 6 have the maximum and broad activities against Gram-positive and Gram-negative bacterial strains.