MMP-2 and MMP-9 activity is regulated by estradiol and tamoxifen in cultured human breast cancer cells
β Scribed by Ulrika W Nilsson; Stina Garvin; Charlotta Dabrosin
- Publisher
- Springer US
- Year
- 2006
- Tongue
- English
- Weight
- 255 KB
- Volume
- 102
- Category
- Article
- ISSN
- 0167-6806
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract P450 aromatase catalyzes the conversion of androgens to estrogens and plays a key role in the cell growth of hormoneβdependent breast cancer in postmenopausal women. On the other hand, matrix metalloproteinases (MMPs), which can degrade almost all components of the extracellular matrix,
bcl-2 expression is often associated with poor prognosis in several types of tumors; however, the role of this molecule in breast cancer is still controversial. We found earlier that over-expression of bcl-2 in a human breast-cancer cell line (MCF7 ADR ) enhances its tumorigenicity and metastatic po
## Abstract Previously we determined that plasma MMPβ9 activity was significantly elevated in breast cancer patients compared to benign mammary pathologies and healthy controls. Now we analyzed its potential usefulness in the followβup and in the prognosis of these patients. MMPβ9 activity was meas
Fibrosis occurs in most chronic liver injuries and results from changes in the balance between synthesis and degradation of extracellular matrix components. In fibrotic livers, there is a markedly increased activity of matrix metalloproteinase 2 (MMP2), a major enzyme involved in extracellular matri