MMP-1, IL-1β, and COX-2 mRNA Expression is Modulated by Static Load in Rabbit Flexor Tendons

ATP modulates load-inducible IL-1β, COX

ATP modulates load-inducible IL-1β, COX 2, and MMP-3 gene expression in human tendon cells

✍ M. Tsuzaki; D. Bynum; L. Almekinders; X. Yang; J. Faber; A.J. Banes 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 165 KB

## Abstract Tendon cells receive mechanical signals from the load bearing matrices. The response to mechanical stimulation is crucial for tendon function. However, overloading tendon cells may deteriorate extracellular matrix integrity by activating intrinsic factors such as matrix metalloproteinas