## Abstract Rare inherited mutations in the __mutL homolog 1__ (__MLH1__) DNA mismatch repair gene can confer an increased susceptibility to colorectal cancer (CRC) with high penetrance where disease frequently develops in the proximal colon. The core promoter of __MLH1__ contains a common single n
MLH1 -93G>A Promoter Polymorphism and the Risk of Microsatellite-Unstable Colorectal Cancer
β Scribed by Raptis, S.; Mrkonjic, M.; Green, R. C.; Pethe, V. V.; Monga, N.; Chan, Y. M.; Daftary, D.; Dicks, E.; Younghusband, B. H.; Parfrey, P. S.; Gallinger, S. S.; McLaughlin, J. R.; Knight, J. A.; Bapat, B.
- Book ID
- 124063584
- Publisher
- Oxford University Press
- Year
- 2007
- Tongue
- English
- Weight
- 164 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0027-8874
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The __MLH1__ β93 G>A promoter polymorphism has been reported to be associated with an increased risk of microsatellite unstable colorectal cancer. Other than microsatellite instability, however, the genetic and most epigenetic changes of tumors associated with this polymorphism have not
## Abstract Polymorphisms in DNA repair genes may be associated with differences in the repair capacity of DNA damage and may thereby influence an individual's susceptibility to smokingβrelated cancer. We investigated the association between the β93GβA polymorphism in the __hMLH1__ gene and the ris