MK-801 protects the neonatal brain from hypoxic-ischemic damage
β Scribed by John W. McDonald; Faye S. Silverstein; Michael V. Johnston
- Book ID
- 115880705
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 149 KB
- Volume
- 140
- Category
- Article
- ISSN
- 0014-2999
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Hypoxic-ischemic brain injury in the perinatal period is a major cause of morbidity and mortality. Presently, there are no proven effective therapies with which to safeguard the human neonatal brain against this type of injury. Minocycline, a semisynthetic tetracycline, has been shown to be neuropro
## Abstract Developing oligodendrocytes (preβOLs) are highly vulnerable to hypoxicβischemic injury and associated excitotoxicity and oxidative stress. 17Ξ²βEstradiol plays an important role in the development and function of the CNS and is neuroprotective. The sudden drop in circulating estrogen aft