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MK-801 prevents levodopa-induced motor response alterations in parkinsonian rats

✍ Scribed by Concepció Marin; Stella Papa; Thomas M. Engber; Mercb Bonastre; Eduardo Tolosa; T.N. Chase

Book ID
113128741
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
585 KB
Volume
736
Category
Article
ISSN
0006-8993

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Chronic dopaminomimetic administration to parkinsonian animal models or Parkinson's disease patients leads to characteristic alteration in motor response. Previous studies suggested that the nonphysiologic stimulation of dopaminergic receptors on striatal medium spiny neurons enhances the synaptic e