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MK-801 induced stereotypies in rats are decreased by haloperidol and increased by diazepam

โœ Scribed by S. Behrens; W. F. Gattaz

Publisher
Springer
Year
1992
Tongue
English
Weight
365 KB
Volume
90
Category
Article
ISSN
1435-1463

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โœ Xia Zhang; Alan A. Boulton; Dong-Mei Zuo; Peter H. Yu ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 720 KB

MK-801 is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist which can prevent excitatory neuronal death. At higher concentrations, however, it can also induce neuronal death in the limbic system. This MK-801-induced selective neurotoxicity has been proposed as an animal model for dem