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(+)-MK-801 induced social withdrawal in rats; a model for negative symptoms of schizophrenia

✍ Scribed by Johan P. Rung; Arvid Carlsson; Katarina Rydén Markinhuhta; Maria L. Carlsson

Book ID
116840507
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
134 KB
Volume
29
Category
Article
ISSN
0278-5846

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(+)-MK-801 induced social withdrawal in
(+)-MK-801 induced social withdrawal in rats; a model for negative symptoms of schizophrenia
✍ Johan P. Rung; Arvid Carlsson; Katarina Rydén Markinhuhta; Maria L. Carlsson 📂 Article 📅 2005 🏛 Elsevier Science 🌐 English ⚖ 134 KB

Dopaminergic agonists and NMDA-receptor antagonists form the basis for the dopamine and glutamate models of schizophrenia, respectively. In human subjects dopaminergic agonists evoke a psychosis resembling positive symptoms of schizophrenia, while NMDAreceptor antagonists produce both positive and n