Synthesis of the orally active spiroindo
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Peter E. Maligres; Ioannis Houpis; Kai Rossen; Audrey Molina; Jess Sager; Veena
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Article
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1997
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Elsevier Science
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French
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The preparation of the Merck Growth Hormone Secretagogue; MK-677 is described. A Fischer indole/reduction based strategy provides the novel spiroindoline nucleus of this potent compound. This optimized sequence necessitates the isolation of only one intermediate 10 and provides MK-677 in 48% overall