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MK-0767, a novel dual PPARα/γ agonist, displays robust antihyperglycemic and hypolipidemic activities

✍ Scribed by Thomas W Doebber; Linda J Kelly; Gaochao Zhou; Roger Meurer; Chhabi Biswas; Ying Li; Margaret S Wu; Marc C Ippolito; Yu-Sheng Chao; Pei-Ran Wang; Samuel D Wright; David E Moller; Joel P Berger


Book ID
116288334
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
261 KB
Volume
318
Category
Article
ISSN
0006-291X

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✍ Jesper B. Kristensen; Steen K. Johansen; Jacob S. Valsborg; Lars Martiny; Christ 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 138 KB

## Abstract Currently, Ragaglitazar is being developed as a drug for the treatment of hyperglycaemia and hyperlipidemia in patients with type 2 diabetes. Here, we report the labelling of Ragaglitazar with carbon‐14 and tritium for in vivo and in vitro investigations. Two different carbon‐14 labelle