𝔖 Bobbio Scriptorium
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Mizoribine in the treatment of rheumatoid arthritis and juvenile idiopathic arthritis

✍ Scribed by Syuji Takei

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
90 KB
Volume
44
Category
Article
ISSN
1328-8067

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✦ Synopsis

Abstract

Background: Mizoribine (MZR), isolated from culture medium of the mold, is a novel immunosuppressant developed in Japan. It has been used in patients with renal transplantation, lupus nephritis, nephrotic syndrome and rheumatoid arthritis (RA).

Objectives: To review MZR in regards to mechanism of action, pharmacokinetics, efficacy and safety in the treatment of rheumatoid RA and juvenile idiopathic arthritis (JIA).

Results: The drug MZR inhibits both humoral and cellular immunity in RA patients. It is completely excreted in the urine within 24 h, which contributes to the safety of MZR. A series of multicenter studies indicated that MZR was effective and safe in the treatment of RA. In JIA, however, there are only a few case reports reporting its efficacy and safety.

Conclusion: A double‐blinded multicenter study is needed to establish the efficacy, safety and indication of MZR in the treatment of JIA.

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