𝔖 Bobbio Scriptorium
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Mixing in the sample loop of the loop-type interface in coupled LC-GC

✍ Scribed by Grob, Konrad ;Artho, Anna ;Le Donne, Patrizia

Book ID
102350476
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
422 KB
Volume
15
Category
Article
ISSN
0935-6304

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✦ Synopsis

Abstract

During introduction of an LC fraction into the sample loop of the loop‐type interface mixing occurs between the fraction of interest and the material previously eluted from the LC. Such mixing may not only result in losses of the solute material of interest, but also in contamination of the fraction of interest with material from which it was supposed to have been isolated. Experimental determination of the extent of mixing has led to the conclusion that whereas the effects are negligible under some conditions, in some circumstances the mixing can cause severe problems.

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✍ Grob, K. ;Stoll, J.-M. πŸ“‚ Article πŸ“… 1986 πŸ› John Wiley and Sons 🌐 English βš– 544 KB

Presently, two coupling techniques are used for directly introducing HPLC fractions into capillary GC: The retention gap technique (involving negligible or partially concurrent solvent evaporation) and fullyconcurrent solvent evaporation. While the former involves use of a conventional on-column inj