Mixed Organofluorine-Organosilicon Chemistry. Part 13. Synthesis of Polyfluorinated Nitrogen-Containing Heterocycles from Hemifluorinated Enones or Organofluorosilicon Building Blocks as Synthetic Equivalents.

✍ Scribed by Frederic Chanteau; Benoit Didier; Boniface Dondy; Pascale Doussot; Richard Plantier-Royon; Charles Portella

• Book ID: 101960387
• Publisher: John Wiley and Sons
• Year: 2004
• Weight: 248 KB
• Volume: 35
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.200432048

✦ Synopsis

Ring closure reactions

Ring closure reactions O 0130

Mixed Organofluorine-Organosilicon Chemistry. Part 13. Synthesis of Polyfluorinated Nitrogen-Containing Heterocycles from Hemifluorinated Enones or Organofluorosilicon Building Blocks as Synthetic Equivalents. -Perfluoroalkyl substituted silanes (I), silyloxyalkene (IV), and enones of type (VI) and (XV) behave as synthetic equivalents in the reaction with different bis(nucleophiles) to give benzodiazepines, benzothiazepines, imidazolidines, oxazolidines, and pyrimidines bearing both a fluorine and a perfluoroalkyl substituent in vicinal positions. -(CHANTEAU, F.;