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Mixed lymphocyte reaction in healthy women with rheumatoid factor. lack of association with hla-dw4

✍ Scribed by Edgar G. Engleman; Ernest E. Sponzilli; Marion E. Batey; Savitri Ramcharan; Hugh O. Mcdevitt

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
310 KB
Volume
21
Category
Article
ISSN
0004-3591

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✦ Synopsis

Abstract

In independent studies, 51% and 36% of patients with rheumatoid arthritis have been shown to possess HLA‐Dw4 compared to 7% and 13% of controls. In one study Dw4 positive patients more frequently had rheumatoid factor in their sera than did Dw4 negative patients. In order to determine if the Dw4 specificity is associated with the disease or with the presence of rheumatoid factor, the frequency of this HLA antigen has been determined in 24 healthy women known to have rheumatoid factor (median titer 1:160). Only 3 were found to have the Dw4 specificity, suggesting that this specificity is not associated with rheumatoid factor in the absence of rheumatoid arthritis.

📜 SIMILAR VOLUMES

HLA–DR4 subtypes in new zealand polynesi
HLA–DR4 subtypes in new zealand polynesians. predominance of dw13 in the healthy population and association of dw15 with rheumatoid arthritis
✍ Paul L. J. Tan; Sarah Farmiloe; Maurice Roberts; Arie Geursen; Margot A. Skinner 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 456 KB 👁 2 views

Objective. To analyze HLA-DR4 alleles in New Zealand Polynesians with rheumatoid arthritis (RA). Methods. Thirty Polynesians and 30 Caucasians with RA, as well as 65 Polynesian and 60 Caucasian healthy blood donors, were DR4 subtyped using the polymerase chain reaction and sequence-specific oligonu