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Mixed lineage kinase 3 is required for matrix metalloproteinase expression and invasion in ovarian cancer cells

✍ Scribed by Yu Zhan; Widian F. Abi Saab; Nidhi Modi; Amanda M. Stewart; Jinsong Liu; Deborah N. Chadee

Book ID
113956249
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
758 KB
Volume
318
Category
Article
ISSN
0014-4827

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## Abstract The ubiquitin‐proteasome pathway (UPP) is involved in the degradation of the extracellular matrix (ECM) and trophoblastic invasion during early pregnancy. Our previous studies demonstrated that inhibition of UPP suppresses expression of matrix metalloproteinase (MMP)‐2 and ‐9. LMP2 is a