Mixed-ligand complexes of boric acid with organic biomolecules

✍ Scribed by Dursun Ali Köse; Birgül Zümreoglu-Karan

• Book ID: 111491545
• Publisher: Versita
• Year: 2012
• Tongue: English
• Weight: 242 KB
• Volume: 66
• Category: Article
• ISSN: 0366-6352
• DOI: 10.2478/s11696-011-0108-0

✦ Synopsis

Abstract

Boric acid forms meta-stable complexes with biomolecules like amino and hydroxy acids and stable complexes with the diol group containing carbohydrates, vitamins, and nucleotides, yielding mono-chelate (1: 1 complex) or bis-chelate (1: 2 complex) structures with negatively charged tetrahedral borate anions. Here we report water-soluble, bio-available mixed-ligand boron adducts for potential nutritional and/or pharmaceutical applications. The complexes were prepared by complete esterification of boric acid with a number of acyclic- and cyclic hydroxy-functionalized biomolecules employing sodium as the counter ion. Structural and thermal properties of the complexes were investigated using chemical analysis, 11B NMR, FTIR, and TGA-DTA techniques. Complexes containing salicylic acid as one of the ligands displayed higher thermal and hydrolytic stabilities.