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Mixed agonist/antagonist properties of NAN-190 at 5-HT1A Receptors: Behavioural and in vivo brain microdialysis studies

โœ Scribed by Stephan Hjorth; Trevor Sharp


Book ID
118344125
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
671 KB
Volume
46
Category
Article
ISSN
0024-3205

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Flibanserin (BIMT 17) has been described as a 5-HT 1A agonist with preferential affinity for postsynaptic 5-HT 1A receptors and as a 5-HT 2A antagonist. Indeed, using the forskolin-stimulated cAMP accumulation technique, flibanserin but not the 5-HT 1A agonists buspirone and 8-OH-DPAT had agonistic