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Mitsunobu Synthesis of Symmetrical Alkyl and Polyfluoroalkyl Secondary Amines.

✍ Scribed by Ana-Maria Balint; Andrea Bodor; Agnes Goemoery; Karoly Vekey; Denes Szabo; Jozsef Rabai


Publisher
John Wiley and Sons
Year
2006
Weight
18 KB
Volume
37
Category
Article
ISSN
0931-7597

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## Abstract The chemoselective __N__‐alkylation of __tert__‐alkylamines applying aliphatic amines is described for the first time. In the presence of the Shvo catalyst **1**, __tert__‐octylamine **4** and 1‐adamantylamine **5** are alkylated using primary, secondary, and even tertiary amines to giv