✦ LIBER ✦
Mitoxantrone toxicity on ehrlich ascites tumour cells: Inhibition of the transplasma membrane redox activity
✍ Scribed by Miguel Angel Medina; Pilar Luque; Ignacio NÚñez De Castro
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 306 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0263-6484
No coin nor oath required. For personal study only.
✦ Synopsis
This study focused on the potent cytotoxic effect that mitoxantrone produces on Ehrlich ascites tumour cells. Host mice treated with mitoxantrone showed a life span three times higher than control non-treated host mice. Mitoxantrone also showed a potent cytotoxic effect on Ehrlich cells incubated in vitra for only a few hours. Studies on the effect of mitoxantrone on a plasma membrane redox system showed that mitoxantrone inhibits this activity, which is apparently related to cell proliferation.