Mitoxantrone and etoposide: An effective regimen for refractory or relapsed acute myelogenous leukemia
โ Scribed by M. Lazzarino; E. Morra; E. P. Alessandrino; E. Orlandi; G. Pagnucco; S. Merante; P. Bernasconi; D. Inverardi; M. Bonfichi; C. Bernasconi
- Book ID
- 114791113
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 413 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0902-4441
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Seventeen patients with relapsed or refractory acute nonlymphocytic leukemia were treated with 14 mg/m2 of mitoxantrone given in a 30-minute infusion daily for three days. If the day fourteen bone marrow showed residual leukemia, a second course was given at the same dose for two days. Eight patient
## Background: One potential mechanism of drug resistance to chemotherapy is the overexpression of multidrug resistance (mdr) genes coding for p-glycoprotein (p-gp), which leads to reduced intracellular retention of chemotherapy. this study tested the efficacy and toxicity of mitoxantrone, etoposid