Mitotic index and size in regenerating amphibian limbs

✍ Scribed by Litwiller, Raymond

• Book ID: 102888983
• Publisher: John Wiley and Sons
• Year: 1939
• Tongue: English
• Weight: 613 KB
• Volume: 82
• Category: Article
• ISSN: 0022-104X
• DOI: 10.1002/jez.1400820206

✦ Synopsis

Careful descriptive and experimental studies of limb regeneration in amphibians have been reported by Fritsch ( 'll), Weiss ( '25), Schott6 ('26), Hellmich ('30) and others. Little is known of the regeneration process in terms of cell counts and rates of division a t various levels of regenerating limbs and with limbs of varying ages of regeneration. The purpose of this work is to supply this information.

Limb regeneration furnishes an ideal means of studying cellular division in relation to limb volume changes. The main features of limb regeneration have been well summarized by Weiss ('30, '39) and need not be repeated here except to say: 1) Wound covering occurs by migration of epidermis cells over the wound and is not marked by extensive cell division. 2) All the later constituents of the regenerated limb, with the exception of the entering nerve fibers, epithelium and perhaps blood cells, arise from the blastema mesenchyme cells at. the base of the wound covering.