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Mitotic drug targets and the development of novel anti-mitotic anticancer drugs

✍ Scribed by Mathias Schmidt; Holger Bastians

Book ID
116413271
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
797 KB
Volume
10
Category
Article
ISSN
1368-7646

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## Abstract The ubiquitin-proteasome system is responsible for the degradation of most intracellular proteins, including those that control cell cycle progression, apoptosis, signal transduction and the NF-ΞΊB transcriptional pathway. Aberrations in the ubiquitin-proteasome system underlie the patho