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Mitosis of maternal lymphocytes in the presence of fetal cells: Possible implication in prenatal diagnosis from fetal blood samples

✍ Scribed by J. P. Chaudhuri; K. D. Zang

Publisher: Springer
Year: 1976
Tongue: English
Weight: 224 KB
Volume: 34
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00295295

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✦ Synopsis

The suppression of proliferation of maternal lymphocytes by the lymphocytes of their own male newborns have been tested in a PHA-induced two-way stimulation system. The mixed lymphocyte cultures of 6 out of 12 such mothers/son pairs had 23--50% metaphases with 46,XX karyotype. In 2 more cases 10% maternal metaphases have been observed. Hence, it appears that fetal lymphocytes are unable to suppress the proliferation of maternal cells completely.

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