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Mitogens generate positive and negative signals for human hepatic stellate cell proliferation

✍ Scribed by A Mallat; C Gallois; T Jiangchuang; A Habib; J Maclouf; P Mavier; A-M Préaux; S Lotersztajn


Book ID
118568293
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
166 KB
Volume
28
Category
Article
ISSN
0168-8278

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Insulin and insulin-like growth factor-1
✍ Gianluca Svegliati-Baroni; Francesco Ridolfi; Antonio Di Sario; Alessandro Casin 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 323 KB

Insulin and insulin-like growth factor (IGF-1) are mitogenic for fibroblasts and smooth muscle cells. IGF-1 increases in inflamed and fibrotic tissues and induces proliferation of rat hepatic stellate cells (HSC). This study evaluates the potential roles of these hormones in the development of liver