✦ LIBER ✦

Mitogenic effect of a growth factor derived from myelin on denervated regenerates of newt forelimbs

✍ Scribed by Mescher, Anthony L. ;Gospodarowicz, Denis

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 313 KB
Volume: 207
Category: Article
ISSN: 0022-104X
DOI: 10.1002/jez.1402070318

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Fibroblast growth factor injected into denervated early regenerates of adult newt forelimbs promotes mitotic activity in the dedifferentiated mesodermal cells. The effect is dose‐dependent and is not produced with similar doses of cytochrome c, bovine serum albumin, or growth hormone. Epidermal growth factor has a mitogenic effect less than half as great as that of fibroblast growth factor. The results suggest the possibility of a role for myel in‐derived growth factors in blastema formation.

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