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Mitogen requirement for cell cycle progression in the absence of pocket protein activity

✍ Scribed by Floris Foijer; Rob M.F. Wolthuis; Valerie Doodeman; René H. Medema; Hein te Riele


Book ID
113523640
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
32 KB
Volume
9
Category
Article
ISSN
1535-6108

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## Abstract The serine/threonine kinase PAK4 regulates cytoskeletal architecture, and controls cell proliferation and survival. In most adult tissues PAK4 is expressed at low levels, but overexpression of PAK4 is associated with uncontrolled proliferation, inappropriate cell survival, and oncogenic