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Mitogen induced activation, proliferation and surface antigen expression patterns in unmutated and hypermutated chronic lymphocytic leukemia cells

✍ Scribed by Juhani Vilpo; Gerard Tobin; Janne Hulkkonen; Mikko Hurme; Ulf Thunberg; Christer Sundström; Leena Vilpo; Richard Rosenquist

Book ID: 114792845
Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 156 KB
Volume: 75
Category: Article
ISSN: 0902-4441
DOI: 10.1111/j.1600-0609.2005.00443.x

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Background: Programmed cell death (PCD) is characterized by a sequence of tightly regulated events that result in the activation of caspases and in internucleosomal DNA cleavage. Late apoptotic events such as DNA-strand breaks can be assayed by in situ end labeling (ISEL) and DNA measurement (sub G1