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Mitogen-Activated Protein Kinase Phosphatase-1 and the Redox Regulation of Monocyte Adhesion and Migration

✍ Scribed by Seok Kim, Hong; Ullevig, Sarah; Zamora, Debora; Fung Lee, Chi; Asmis, Reto


Book ID
123581007
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
205 KB
Volume
53
Category
Article
ISSN
0891-5849

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## Abstract ## Objective Mitogen‐activated protein kinases (MAPKs) are activated by proinflammatory stimuli. MAPK phosphatases (MKPs), in particular MKP‐1, have been identified as endogenous negative regulators of MAPK activation. Since MAPKs are known to be important in rheumatoid arthritis (RA)