Mitogen-activated protein kinase pathway mediates N-(4-hydroxyphenyl)retinamide-induced neuronal differentiation in the ARPE-19 human retinal pigment epithelial cell line

Decreased expression of insulin-like gro

Decreased expression of insulin-like growth factor binding protein-5 during N-(4-hydroxyphenyl)retinamide-induced neuronal differentiation of ARPE-19 human retinal pigment epithelial cells: Regulation by CCAAT/enhancer-binding protein

✍ William Samuel; R. Krishnan Kutty; Camasamudram Vijayasarathy; Iranzu Pascual; T 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 292 KB 👁 2 views

## Abstract Insulin‐like growth factor (IGF)‐binding protein‐5 (IGFBP5), an important member of the IGF axis involved in regulating cell growth and differentiation, acts by modulating IGF signaling and also by IGF‐independent mechanisms. We identified IGFBP5 by microarray analysis as a gene differe