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Mitogen-activated protein kinase is involved in N-methyl-d-aspartate receptor regulation of amyloid precursor protein cleavage

✍ Scribed by J Mills; P.B Reiner


Book ID
117493187
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
186 KB
Volume
94
Category
Article
ISSN
0306-4522

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## Abstract Low‐level activation of __N__‐methyl‐d‐aspartate receptors (NMDARs) results in a decrease in the ability of tetanic stimulation to induce long‐term potentiation (LTP). This NMDAR‐mediated LTP inhibition is observed with low micromolar concentrations of NMDA or chelation of ambient extra