## Abstract ## BACKGROUND The mitogenβactivated protein kinase (MAPK) cascade is activated in response to various extracellular stimuli. The authors investigated the involvement of the p38 MAPK, a member of the MAPK superfamily, cascade in hepatoma cell lines and in human hepatocellular carcinoma
Mitogen-activated protein kinase cascade and cell cycle-related genes in the kidney
β Scribed by Yoshio Terada; Osamu Nakashima; Seiji Inoshita; Michio Kuwahara; Sei Sasaki; Fumiaki Marumo
- Book ID
- 105590076
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 755 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1342-1751
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Mitogen-activated protein (MAP) kinases are serine/threonine protein kinases that are activated rapidly in cells stimulated by various extracellular signals. With stimulation of quiescent cells by growth factors, activated p42/p44 MAP kinases rapidly translocate to the nucleus, where they induce imm
## Abstract The hedgehog and mitogenβactivated protein kinase (MAPK) signaling pathways regulate growth in many tumors, suggesting cooperation between these two pathways in the regulation of cell proliferation. However, interactions between these pathways have not been extensively studied. We asses