Mitochondrial uptake of rhodamine 123 by rabbit articular chondrocytes

Monitoring the effect of anti-cancer dru

Monitoring the effect of anti-cancer drugs on L1210 cells by a mitochondrial probe, rhodamine-123

✍ Samuel D. Bernal; Howard M. Shapiro; Lan Bo Chen 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 French ⚖ 664 KB

## Abstract The cancer chemotherapeutic agents 1‐β‐D‐arabinofuranosylcytosine (Ara‐C), methotrexate, and 5‐fluorouracil cause a rapid loss of mitochondrial Rh‐123 uptake in L1210 cells, which correlates with the loss of clonogenic ability. The loss of Rh‐123 uptake is irreversible and occurs prior