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Mitochondrial targeting of human protoporphyrinogen oxidase

✍ Scribed by Lester M. Davids; Anne V. Corrigall; Peter N. Meissner


Book ID
108084481
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
474 KB
Volume
30
Category
Article
ISSN
1065-6995

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A respiratory-defective mutant (C54) of Saccharomyces cerevisiae was found to have a phenotype consistent with a mutation in either mitochondrial protoporphyrinogen oxidase or ferrochelatase. The mutant is grossly deficient in hemes, accumulates protoporphyrin and is rescued by exogenous heme. The i