bcl-2 inhibits mitochondrial metabolism
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Annamaria Biroccio; Donatella Del Bufalo; Maurizio Fanciulli; Tiziana Bruno; Gab
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Article
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1999
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John Wiley and Sons
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French
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Lonidamine (LND), a selective inhibitor of the energy metabolism of tumor cells, induces apoptosis, independently of the p53 gene, in the adriamycin(ADR)-resistant MCF7 breast-cancer cell line (MCF7 ADR). On the contrary, LND fails to activate the apoptotic program in the parental MCF7-sensitive cel