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Mitochondrial regulation of cell death: Processing of apoptosis-inducing factor (AIF)

✍ Scribed by Erik Norberg; Sten Orrenius; Boris Zhivotovsky


Book ID
116299992
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
297 KB
Volume
396
Category
Article
ISSN
0006-291X

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## Abstract Apoptosis‐inducing factor (AIF) is expelled from mitochondria after some apoptotic stimuli and translocates to the nucleus, which may contribute to DNA and nuclear fragmentation in some non‐physiological mammalian cell deaths. Conversely, the requirement for mitochondrial AIF in oxidati