✦ LIBER ✦

Mitochondrial pathology in Parkinson's disease and implications for therapeutic intervention

✍ Scribed by Russell H. Swerdlow; W. Davis Parker Jr.

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 87 KB
Volume: 46
Category: Article
ISSN: 0272-4391
DOI: 10.1002/(sici)1098-2299(199901)46:1<44::aid-ddr7>3.0.co;2-6

No coin nor oath required. For personal study only.

✦ Synopsis

Although the ultimate origin and role of mitochondrial pathology in Parkinson's disease (PD) remains controversial, accumulating data suggest that mitochondrial dysfunction is genetic and plays an important role in neurodegeneration. PD mitochondria display abnormal electron transport chain activity, increased reactive oxygen species generation, and abnormal calcium handling. These abnormalities arise, at least in part, from information encoded by mitochondrial DNA. These processes are implicated in current models of neuronal death and validate ongoing efforts to develop mitochondrial-level pharmacologic interventions for the treatment of this disease. Drug Dev. Res. 46:44-50, 1999.

📜 SIMILAR VOLUMES

Core assessment program for surgical int

Core assessment program for surgical interventional therapies in Parkinson's disease (CAPSIT-PD)

✍ Gilles-Louis Defer; Hakan Widner; Rose-Marie Marié; Philippe Rémy; Marc Levivier 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 159 KB 👁 1 views

Glutathione in Parkinson's disease: A li

Glutathione in Parkinson's disease: A link between oxidative stress and mitochondrial damage?

✍ Dr. Donato A. Di Monte; Piu Chan; Martha S. Sandy 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 500 KB 👁 1 views

Several links exist between the two mechanisms of neuronal degeneration (i.e., oxygen radical production and mitochondrial damage) proposed to have a role in Parkinson's disease. Indeed, mitochondria are critical targets for the toxic injury induced by oxygen radicals, and experimental evidence sugg

Loss of olfaction in de novo and treated

Loss of olfaction in de novo and treated Parkinson's disease: Possible implications for early diagnosis

✍ G. Tissingh; H.W. Berendse; P. Bergmans; R DeWaard; B. Drukarch; J.C. Stoof; E.C 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 116 KB 👁 1 views

Mitochondrial function in Huntington's d

Mitochondrial function in Huntington's disease: Clues for pathogenesis and prospects for treatment

✍ A. H. V. Schapira 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 228 KB 👁 1 views

Pathological τ proteins in postencephali

Pathological τ proteins in postencephalitic parkinsonism: Comparison with Alzheimer's disease and other neurodegenerative disorders

✍ Valérie Buée-Scherrer; Dr. Luc Buée; Bátrice Leveugle; Daniel P. Perl; Patrick V 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 500 KB 👁 1 views

Therapeutic and “dose-dependent” effect

Therapeutic and “dose-dependent” effect of repetitive microelectroshock induced by transcranial magnetic stimulation in Parkinson's disease

✍ Judit Mally; T. W. Stone 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 84 KB 👁 1 views

Transcranial magnetic stimulation (TMS) has been used in the diagnosis of neurological lesions and has been introduced into the therapy of central nervous diseases. Lately it has been claimed that TMS would be useful not only in the treatment of depression, but also in relieving symptoms of Parkinso