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Mitochondrial myopathy caused by clevudine therapy in chronic hepatitis B patients

✍ Scribed by Won Young Tak; Soo Young Park; Min Kyu Jung; Seong Woo Jeon; Chang Min Cho; Young Oh Kweon; Sung Kook Kim; Yong Hwan Choi

Book ID
118088140
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
300 KB
Volume
39
Category
Article
ISSN
1386-6346

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Long-term therapy with clevudine for chr
Long-term therapy with clevudine for chronic hepatitis B can be associated with myopathy characterized by depletion of mitochondrial DNA
✍ Jung Im Seok; Dong Kuck Lee; Chang Hyeong Lee; Min Su Park; Sun Young Kim; Hyang πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 426 KB

Clevudine (Revovir), a pyrimidine nucleoside analogue, is a recently introduced antiviral drug. Clinical trials have demonstrated potent, sustained antiviral activity against hepatitis B virus without specific adverse events. The lack of cytotoxicity and absence of an effect on mitochondrial functio