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Mitochondrial malic enzyme in mosaic skeletal muscle of mouse chimeras

✍ Scribed by P. M. Frair; P. M. Strasberg; K. B. Freeman; A. C. Peterson

Publisher
Springer
Year
1979
Tongue
English
Weight
526 KB
Volume
17
Category
Article
ISSN
0006-2928

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✦ Synopsis

The question was investigated whether mitochondria in the mammalian skeletal muscle fiber syncytium ineorporate gene products encoded by one or many nuclei. Mouse chimeras were produced from strains which differ in their electrophoretic variants of the nuclear-coded mitochondrial protein, malic enzyme (MOD-2, E.C. 1.1.1.40, L-malate NADP + oxidoreductase decarboxylating). The MOD-2'phenotypes of skeletal muscles of these chimeras were characterized in a starch gel electrophoretic system. The results indicate that individual mitochondria can contain products encoded by multiple nuclei and therefore that, for skeletal muscle mitochondria, the,cell is not subdivided into nuclear territories. Possible mechanisms of gene product distribution in skeletal muscle fibers are discussed.

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