Mitochondrial Involvement in Causing Cell Injury in Experimental Hepatic Iron Overload
โ Scribed by A. MASINI; T. TRENTI; D. CECCARELLI; U. MUSCATELLO
- Book ID
- 118724305
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 134 KB
- Volume
- 488
- Category
- Article
- ISSN
- 0890-6564
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๐ SIMILAR VOLUMES
Peroxidative decomposition of mitochondrial membrane phospholipids with subsequent mitochondrial dysfunction is a postulated mechanism of liver cell injury in parenchymal iron overload. Malondialdehyde is formed when polyunsaturated fatty acids of membrane phospholipids undergo peroxidative decompos
Both human porphyria cutanea tarda and experimental hexachlorobenzene-induced porphyria are associated with hepatic injury and are potentiated by excess hepatic iron. The mechanisms whereby cellular injury occurs and the synergistic role of iron overload are unknown. In the present experiments, we s