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Mitochondrial glutathione depletion in alcoholic liver disease

✍ Scribed by Fernández-Checa, JoséC.; Hirano, Takeshi; Tsukamoto, Hidekazu; Kaplowitz, Neil

Book ID
123594104
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
686 KB
Volume
10
Category
Article
ISSN
0741-8329

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Hepatic mitochondrial glutathione deplet
Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats
✍ Akeshi Hirano; Neil Kaplowitz; Hidekazu Tsukamoto; Seiichiro Kamimura; Jose C. F 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 487 KB 👁 1 views

Long-term ethanol feeding has been shown to selectively reduce hepatic mitochondrial glutathione content by impairing mitochondrial uptake of this thiol. In this study, we assessed the role of this defect in evolution of alcoholic liver disease by examining the mitochondrial glutathione pool and lip