Mitochondrial gene linked to rare hereditary tumour
β Scribed by Kathryn Senior
- Book ID
- 114381819
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 19 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1357-4310
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## Abstract Mammalian mitochondrial DNA encodes 37 essential genes required for ATP production via oxidative phosphorylation, instability or misregulation of which is associated with human diseases and aging. Other than the mtDNAβencoded RNA species (13 mRNAs, 12S and 16S rRNAs, and 22 tRNAs), the
Mutations in the gene encoding the transmembranous cell adhesion molecule, myelin protein zero (Po), have been reported in patients with Charcot-Marie-Tooth disease types 1 B and 3 (Dejerine-Sottas disease). We have previously shown that the targeted deletion of the Po gene in mice results in impair