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MITOCHONDRIAL FUNCTION IN PARKINSON'S DISEASE

✍ Scribed by Bindoff, L.A.; Birch-Machin, M.; Cartlidge, N.E.F.; Parker, W.D.; Turnbull, D.M.

Book ID
122843318
Publisher
The Lancet
Year
1989
Tongue
English
Weight
175 KB
Volume
334
Category
Article
ISSN
0140-6736

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## Abstract Reports on mitochondrial respiratory chain (MRC) complex I (CI) dysfunction in the substantia nigra in Parkinson's disease (PD) support the oxidative stress hypothesis in the neuropathogenesis of PD. Studies in peripheral tissue have found variable decreased CI and occasionally other co