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Mitochondrial Dysfunction: The First Domino in Brain Aging and Alzheimer's Disease?

✍ Scribed by Leuner, Kristina; Hauptmann, Susanne; Abdel-Kader, Reham; Scherping, Isabel; Keil, Uta; Strosznajder, Johanna B.; Eckert, Anne; Müller, Walter E.

Book ID
115502892
Publisher
Mary Ann Liebert
Year
2007
Tongue
English
Weight
479 KB
Volume
9
Category
Article
ISSN
1523-0864

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## Abstract Aging of mammalian brain is associated with a continuous decrease of the capacity to produce ATP by oxidative phosphorylation. The impairment of mitochondrial function is mainly due to diminished electron transfer by complexes I and IV, whereas inner membrane H^+^ impermeability and F~1