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Mitochondrial dysfunction is involved in P2X7 receptor-mediated neuronal cell death

✍ Scribed by Kentaro Nishida; Tsunetoshi Nakatani; Akihiro Ohishi; Hiroto Okuda; Youichirou Higashi; Takaaki Matsuo; Sadaki Fujimoto; Kazuki Nagasawa

Book ID
115270903
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
808 KB
Volume
122
Category
Article
ISSN
0022-3042

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## Abstract The P2X~7~ receptor has been implicated in the release of cytokines and in the induction of cell death, and is up‐regulated in a transgenic mouse model of Alzheimer's disease. Using cocultures of rat cortical neurons and microglia, we show that ATP and the more potent P2X~7~ agonist ben