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Mitochondrial Dysfunction in Neurodegenerative Disorders || Mitochondria, Sodium, and Calcium in Neuronal Dysfunction

✍ Scribed by Reeve, Amy Katherine; Krishnan, Kim Jennifer; Duchen, Michael R.; Turnbull, Doug M


Book ID
118256443
Publisher
Springer London
Year
2011
Tongue
English
Weight
335 KB
Edition
2012
Category
Article
ISBN
0857297015

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✦ Synopsis


As age related diseases increase in prevalence and impact more significantly on medical resources it is imperative to understand these diseases and the mechanisms behind their progression. New research has stimulated a growing interest in mitochondrial involvement in neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease and multiple sclerosis and the mechanisms which lead from mitochondrial dysfunction to neurodegeneration. Mitochondrial Dysfunction in Neurodegenerative Disorders brings together contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of these diseases, guiding the reader through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, to the consequences of this dysfunction on neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.


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