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Mitochondrial dysfunction in mouse trisomy 16 brain

โœ Scribed by L.L. Bambrick; G. Fiskum


Book ID
113503153
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
456 KB
Volume
1188
Category
Article
ISSN
0006-8993

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## Abstract Aging of mammalian brain is associated with a continuous decrease of the capacity to produce ATP by oxidative phosphorylation. The impairment of mitochondrial function is mainly due to diminished electron transfer by complexes I and IV, whereas inner membrane H^+^ impermeability and F~1