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Mitochondrial dysfunction in brain aging: Role of oxidative stress and cardiolipin

✍ Scribed by Giuseppe Paradies; Giuseppe Petrosillo; Valeria Paradies; Francesca M. Ruggiero

Book ID
116765624
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
525 KB
Volume
58
Category
Article
ISSN
0197-0186

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## Abstract Aging of mammalian brain is associated with a continuous decrease of the capacity to produce ATP by oxidative phosphorylation. The impairment of mitochondrial function is mainly due to diminished electron transfer by complexes I and IV, whereas inner membrane H^+^ impermeability and F~1