## Abstract Cdk5, a member of the cyclinโdependent kinase (cdk) family, is predominately active in neurons, where its activity is tightly regulated by the binding of its neuronal activators p35 and p39. Cdk5 is implicated in regulating the proper neuronal function; a deregulation of cdk5 has been f
โฆ LIBER โฆ
Mitochondrial Dysfunction Enhances Susceptibility to Oxidative Stress by Down-Regulation of Thioredoxin in Human Neuroblastoma Cells
โ Scribed by Hongqun Ding; Jing Gao; Zengrong Zhu; Yuyun Xiong; Jiankang Liu
- Book ID
- 106483759
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 392 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0364-3190
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## Abstract In vivo administration of the mitochondrial inhibitor 3โnitropropionic acid (3โNP) produces striatal pathology mimicking Huntington's disease (HD). However, the mechanisms of cell death induced by metabolic impairment are not fully understood. Previous studies showed that 3โNP triggered