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Mitochondrial DNA Variants Observed in Alzheimer Disease and Parkinson Disease Patients

✍ Scribed by John M. Shoffner; Michael D. Brown; Antonio Torroni; Marie T. Lott; Margaret F. Cabell; Suzanne S. Mirra; M.Flint Beal; Chi-Chuan Yang; Marla Gearing; Rino Salvo; Ray L. Watts; Jorge L. Juncos; Lawrence A. Hansen; Barbara J. Crain; Michel Fayad; Calvin L. Reckord; Douglas C. Wallace

Book ID
115611668
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
967 KB
Volume
17
Category
Article
ISSN
0888-7543

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The mitochondrial DNA (mtDNA) sequence was determined on 3 patients with Alzheimer's disease (AD) exhibiting AD plus Parkinson's disease (PD) neuropathologic changes and one patient with PD. Patient mtDNA sequences were compared to the standard Cambridge sequence to identify base changes. In the fir